161 articles - From Friday Aug 22 2025 to Friday Aug 29 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Aliment Pharmacol Ther |
|---|
| Am J Gastroenterol |
Spray Cryotherapy Esophageal Consortium (SPEC) Consensus Recommendations for Liquid Nitrogen Spray Cryotherapy in Barrett's Esophagus and Esophageal Cancer using a Modified Delphi Process. After 3 Delphi Rounds, 41 of 42 statements were accepted either in their original version (n = 11) or after modification based on expert input (n = 30). Through a modified Delphi process, we developed expert and evidence-based consensus recommendations to guide safe and appropriate use of LNSC in BE and EC. |
| Endoscopy |
Curriculum for optical diagnosis of esophageal neoplasia and precursor lesions: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement. When using acetic acid chromoendoscopy for Barrett's esophagus inspection, endoscopists should be familiar with the appearance of neoplastic lesions by assessing loss of aceto-whitening and mucosal surface patterns. Endoscopists should train in using the Japanese Esophageal Society (JES) classification to describe esophageal squamous cell lesions, to estimate the likelihood of and degree of dysplasia, and in the case of squamous cell cancer, the invasion depth. |
| Gastroenterology |
AGA Clinical Practice Update on Management of Hepatitis Delta: Commentary. The purpose of this American Gastroenterological Association (AGA) Clinical Practice Update is to facilitate understanding and improve clinical management of patients with hepatitis delta virus infection. This commentary was commissioned and approved by the AGA Institute Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the Clinical Practice Updates Committee and external peer review through standard procedures of Gastroenterology. |
| Gastrointest Endosc |
meta-analyses and systematic reviews
| Clin Gastroenterol Hepatol |
|---|
Prevalence and clinical outcomes of recompensation in decompensated cirrhosis: a systematic review and meta-analysis. Recompensation occurred in approximately one-third of decompensated cirrhosis patients who achieved etiological control. Recompensation was associated with lower risk of HCC and death, thus represents a clinically meaningful endpoint in this population. |
| Gastrointest Endosc |
Endoscopic Balloon Dilation Versus Stent Placement in the Management of Dominant Strictures in Primary Sclerosing Cholangitis: A Systematic Review and Meta-Analysis. EBD demonstrated significantly better clinical efficacy with fewer treatment sessions. Stent placement reduces serum bilirubin more than EBD and is used in advanced PSC with severe strictures or EBD failure, potentially indicating more advanced disease. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
Long-Term Follow-Up of Patients in a Prospective Study of NA Discontinuation Identifies Different Patterns of HBsAg Loss. ALT flares were associated with HBsAg decline, and in some cases, with delayed HBsAg loss. The clinical study was supported by the National Health and Medical Research Council of the study clinical trial ID is NCT02581033. |
Telemetric Assessment and Comparison of Regional Colonic Metabolic Activity in Ambulant Healthy Individuals Using pH and Gas-Sensing Wireless Motility Capsules. Luminal pH poorly reflects carbohydrate fermentation in the distal colon. ACTRN12619001219178 and ACTRN12622000422729. |
Unveiling Drug-Induced Autoimmune-Like Hepatitis in Autoimmune Hepatitis Patients: A Multicenter Retrospective Study. DI-ALH is often under-recognised in clinical practice, leading to unnecessary long-term immunosuppression. A causal relationship between drugs and AIH, along with an attempt to withdraw treatment and long-term follow-up, is essential to prevent overtreatment-associated risks. |
| Am J Gastroenterol |
Accurate Non-endoscopic Detection of Early Esophageal Squamous Malignant Lesions Using Sponge-based Methylated DNA Biomarkers. The AUCs for the complex model that included the two MDMs and Age were 0.961(95%CI, 0.920 to 1.000) and 0.940 (95%CI, 0.889 to 0.990) in the training and validation sets, respectively. The assay of MDMs in CCD samples offers a highly accurate method of predicting HGIN/ESCC, thereby providing the potential for early diagnosis and screening for HGIN/ESCC. |
Avoidant/restrictive eating in people with and without bowel symptoms in the general population: Prevalence, Clinical Profile and Associated Factors. Avoidant/restrictive eating is common in individuals with bowel symptoms and associated with a more severe clinical profile, indicating a need to discuss eating behavior with patients. However, avoidant/restrictive eating is also common in individuals in the general population without bowel symptoms. |
Diagnostic Accuracy of Spleen-dedicated 100 Hz Transient Elastography to Predict High-risk Esophageal Varices. SSM alone can accurately predict HREV in cirrhosis, and its combination with LSM and PC precisely predicted CSPH, saving a significant number of endoscopies. The SSM cut-off to rule out HREV may vary with etiology. |
Distinct Clinical Phenotypes in Lactase Non-Persistence: Symptomatic, Asymptomatic, and Gassy-Asymptomatic. classifying LNP individuals into distinct subgroups and incorporating hydrogen production rate into breath-test interpretation may enhance diagnostic precision, prevent unnecessary dietary restrictions and generate new hypotheses linking fermentation kinetics and symptoms. Microbiome associations remain correlative and warrant functional validation in larger, controlled studies. |
Effect of oral proton pump inhibitor administration on reducing the delayed bleeding risk in five upper gastrointestinal endoscopic treatments. The subgroup and sensitivity analyses almost consistently confirmed the main results. Oral PPI administration contributed to reducing delayed bleeding risk in G-EMR and G-ESD, but not in E-EMR, E-ESD, and PEG. |
Evolution of Hepatitis A-Related Acute Liver Failure in North America Over 22 Years. Overall, the number of HAV ALF cases enrolled steeply declined. After 2010, when we began recording acute liver injury (ALI: INR ≥ 2 but no encephalopathy) an apparent increase in ALI incidence was noted, despite a near absence of ALF cases. |
Fatty pancreas disease and the risk of future diseases of the exocrine pancreas: a US matched cohort study. Extra-pancreatic cancer incidence did not differ. FPD is associated with an increased risk of pancreatic cancer, acute pancreatitis, chronic pancreatitis, and incidental pancreatic cysts, independent of obesity or hepatic steatosis, suggesting a potentially causative role of FPD in the pathogenesis of exocrine pancreatic diseases. |
Increased mortality associated with sarcopenia in inflammatory bowel disease: a long-term prospective cohort study. Probable and confirmed sarcopenia increase the risk of long-term mortality in IBD patients. Sarcopenia assessment can help risk stratification for prognosis in older IBD patients. |
New Eczematous Eruption in Patients with Inflammatory Bowel Disease Who Stop Janus Kinase Inhibitors. 2 cases with biopsy-confirmed AD resolved after reinitiation of JAKi therapy and adjunct AD treatments. A subset of IBD patients may have latent susceptibility to AD, unmasked by therapy cessation and potentially triggered by an immune rebound effect. |
Safety of Esophageal Dilation Procedures in Patients on Antithrombotic Therapy: A US Collaborative Network Cohort Study. DAPT was numerically associated with a higher risk of bleeding, but this did not reach statistical significance. These findings aim to inform the clinical decision-making in pre- and post-procedure management of esophageal dilation procedures. |
TIMING THE SCAN: OPTIMIZING SCREENING FOR OSTEOPOROSIS AND RISK OF FRACTURE IN CELIAC DISEASE. However, their use should be weighed against an underdetection of clinically relevant BMD alterations. Tailoring DXA timing to healthcare resources and patient demographics may optimize outcomes and resource allocation. |
The Portal Hypertension Decompensation Score - A Validated Predictive Model of Liver Decompensation Related to Portal Hypertension. The PDS is an accurate predictor of decompensation in cACLD. It discriminates patients who are low-risk from those who are high-risk and who may benefit from further evaluation or treatment, without requiring the use of LSM. |
The impact of integrating pelvic MRI at diagnosis on early detection of perianal Crohn's disease in pediatrics. These patients needed more and earlier perianal surgery and had higher biologic use despite their perianal disease being subclinical. Adding routine MR imaging at time of pediatric CD diagnosis may help inform treatment decisions and improve these outcomes. |
| Clin Gastroenterol Hepatol |
Artificial Intelligence for Quantifying Endoscopic Mucosal Ulceration in Crohn's Disease. Performance of CVE for CD was similar in the SEAVUE validation cohort. CVE provides a means for automated ulceration and mucosal injury quantitation that shows conceptual agreement with SES-CD and offers new capabilities to improve the granularity and personalization of endoscopic disease assessment in CD. |
Real-world comparison of the effectiveness of tofacitinib and ustekinumab in patients with ulcerative colitis: the TORUS study. Tofacitinib and ustekinumab are similarly effective to induce and maintain CFREM after anti-TNF failure in UC. However, tofacitinib could be favored in case of multiple therapeutic failures (≥ 3 biologics) and primary failure to any biologic. |
| Endoscopy |
Endoscopic management of refractory gastrointestinal-tracheobronchial fistulas with two novel occluders: a comparative cohort study. All procedure-related AEs were mild, occurring in five DU (13.9%) and three MU patients (6.0%). The MU occluder showed greater potential for sustained occlusion than the DU occluder and may be a viable option for refractory GI-tracheobronchial fistulas, although further prospective studies are needed. |
Reducing the environmental impact of gastrointestinal endoscopy: a prospective study on waste management through waste segregation and staff education. Targeted interventions such as staff education and structured waste segregation protocols substantially reduced RMW and associated GHG emissions in a high-volume endoscopy unit. These results suggest that simple, low-cost changes may improve environmental sustainability in clinical practice. |
STAndardization of Reports (the STAR project) Upper gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative. A suggestion for a normal findings report is provided. Standardized reporting could enhance the quality of UGI endoscopy. |
Training esophagogastroduodenoscopy skills: a randomized multicenter trial comparing simulation-based training versus clinical training. SBT prior to CBT reduces the number of supervised procedures required to achieve independent procedural completion without negatively affecting patient satisfaction or increasing training costs. These findings support the routine implementation of SBT when learning EGD. |
Water consumption before-and-after simple intervention using infographic poster during bowel preparation for colonoscopy: A prospective observational study. No significant differences were observed in fluid intake or bowel cleansing quality. The educational poster intervention promoting appropriate flush selection during bowel preparation may be a simple option for reducing water consumption, leading to green endoscopy. |
| Gastroenterology |
Implications of shame for patient reported outcomes in Bowel Disorders of Gut-Brain Interaction. Shame appears to be a particularly important emotion deriving from the experience of GI symptoms in Bowel DGBI, influencing the associations between these symptoms and important patient reported outcomes. An empathetic doctor-patient relationship and psychological therapies may be helpful for individuals with Bowel DGBI experiencing high levels of shame. |
| Gastrointest Endosc |
Clinical utility of suprapapillary plastic stents for lifelong biliary drainage in unresectable malignant hilar biliary obstruction. SPPS, as the first stent for unresectable MHBO, was considered superior to SEMS for the intermittent maintenance of LBD. Achieving LBD success or extending TLBDF may help preserve therapeutic options. |
Comparison of endoscopic band ligation versus over-the-scope clip for colonic diverticular bleeding: A propensity score-matched cohort analysis. No significant differences in initial hemostasis, requirements for IVR or surgery, requirements of red blood cell transfusion, and adverse events were observed between the two groups. OTSC was more effective than EBL for reducing early recurrent bleeding rate in endoscopic hemostasis for CDB. |
Focused communication Three-dimensional volume estimates of pancreatic fluid collections in relation to clinical outcomes of endoscopic ultrasound-guided treatment. The maximum diameter represented a comparable model goodness-of-fit. PFC volume was associated with the outcomes of EUS-guided interventions, and the maximum diameter may be a reasonable surrogate. |
Optimal Interval of Screening Endoscopy for Reducing Gastric Cancer Mortality: A Nationwide Cohort Study. Patients who underwent screening at intervals ≤3 years had a significantly reduced risk of GC-specific mortality compared to those screened at intervals >3 years. A 3-year screening interval may be an effective strategy for high-risk regions. |
Performance comparison of quantitative and qualitative fecal immunochemical tests in community-based colorectal cancer screening. QnFIT exhibited lower positivity, higher DR at colonoscopy and PPV for CRC over qlFIT. Almost half of colonoscopy resources were saved by qnFIT, although adenoma and polyp were missed in population screening. |
| Gut |
Comparative risk of high-risk neoplasia after polypectomy among individuals aged below 50 years versus 50 years and older. Among screened individuals, in both age groups, the association was particularly strong for individuals with index high-risk lesions and peaked at 3 years after polypectomy, with HRs (95% CI) of 4.60 (3.63 to 5.84) and 5.59 (3.89 to 8.03) for young adults with index high-risk adenoma and high-risk SPs, respectively. Patients undergoing polypectomy at a screening colonoscopy below age 50 years exhibited a similarly increased risk of metachronous neoplasia as those aged ≥50 years, suggesting that current surveillance guidelines developed in old adults may apply to young adults. |
Single-cell multimodal analysis reveals the dynamic immunopathogenesis of HBV-ACLF progression. Six immune cellular modules (CMs) were identified for patient stratification, with CM2 and CM6 showing strong predictive value for disease outcomes, and CM3 indicating a potential early therapeutic window. Our longitudinal multiomics study revealed the dynamic evolution of the immune response in HBV-ACLF and characterised diverse immune patterns for the future precise management and therapeutic intervention. |
Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota. We demonstrated that smoking affects the gut immune system by modulating mucosal microbiota. Our findings provide insights into how smoking can have beneficial or detrimental effects on UC or CD, respectively, and may shed light on the reasons why individuals with UC who quit smoking experience disease exacerbation. |
| Hepatology |
A novel mechanism involving USP53-regulated BSEP trafficking underlies low-GGT intrahepatic cholestasis. Loss of USP53 interaction with MYO5B and its p.(Arg824Cys) variant impaired BSEP trafficking in USP53- and MYO5B-asociated low-GGT intrahepatic cholestasis. These results provide a novel mechanism that underlies USP53-PFIC and implicates USP53 in the pathogenesis of MYO5B-PFIC. |
CX3CR1+ macrophages interact with HSCs to promote HCC through CD8+ T-cell suppression. Moreover, genetic deficiency of CX3CR1 in myeloid cells or pharmacological inhibition of retinol metabolism remarkably attenuated HCC development. We showed that CX3CR1+Ly6C+ macrophages migrate and interact with aHSCs in the peritumoral region where retinoids induce arginase-1 expression in CX3CR1+Ly6C+ macrophages, subsequently depriving CD8+ T cells of arginine and promoting HCC. |
Distinct immune microenvironment of venous tumor thrombus in hepatocellular carcinoma at single-cell resolution. TAMs, especially C5aR+ TAMs, were enriched in PVTT. C5aR+ TAMs contribute to the development of PVTT and poor prognosis by reshaping the immunosuppressive environment. |
Genomic and the tumor microenvironment heterogeneity in multifocal hepatocellular carcinoma. Additionally, MMP9+ tumor-associated macrophages were enriched across IM and MO, which formed cellular niches with regulatory T cells and proliferative/exhausted T cells. Our findings deeply decipher the heterogeneous TMEs between IM and MO, which provide a comprehensive landscape of multifocal HCC. |
Human-induced pluripotent stem cell-based hepatic modeling of lipid metabolism-associated TM6SF2-E167K variant. Our findings indicate that induced hepatocytes generated from human-induced pluripotent stem cells carrying the TM6SF2-E167K recapitulate the effects observed in human hepatocytes from individuals with the TM6SF2 mutation. This study characterizes an in vitro model that can be used as a platform to identify potential clinical targets and highlights the therapeutic potential of targeting protein misfolding to alleviate ER stress and mitigate the detrimental effects of the TM6SF2-E167K mutation on hepatic lipid metabolism. |
Non-Invasive Tests: Establishing efficacy for metabolic dysfunction associated steatohepatitis beyond the biopsy-current perspectives from the division of hepatology and nutrition, US Food and Drug Administration. This communication is intended to provide some of the regulatory considerations on adopting non-invasive tests in lieu of liver histology as a RLSE in drug development for MASH. We will also describe FDA mechanisms and the methods by which data can be submitted to the FDA to consider proposals for NIT use in place of liver histology as RLSEs. |
Plasma FSTL-1 as a noninvasive diagnostic biomarker for patients with advanced liver fibrosis. A cutoff value ≤ 0.43 ng/mL was the optimal rule-out threshold, with a sensitivity of 84.62% (95% CI, 76.46%-90.30%) and a specificity of 79.51% (95% CI, 74.81%-83.53%), while ≥0.50 ng/mL was the best rule-in threshold, with a specificity of 86.41% (95% CI, 81.06%-90.43%) and a sensitivity of 70.67% (95% CI, 64.41%-76.23%). Plasma FSTL-1 has high diagnostic accuracy and could potentially reduce the need for liver biopsy in identifying patients with advanced liver fibrosis. |
Value of HCC surveillance in a landscape of emerging surveillance options: Perspectives of a multi-stakeholder modified Delphi panel. The panel acknowledged performance metrics of emerging methods may differ from other cancer screening programs given differences in populations, including higher risk of cancer development and competing risk of morality, and differences in diagnostic workflow in patients at risk of HCC. These data provide insights into the perceived value of HCC surveillance in an era of emerging blood- and imaging-based surveillance strategies. |
| J Hepatol |
Claudin-1 is a mediator and therapeutic target in primary sclerosing cholangitis. The results of this preclinical study pave the way for the clinical development of Claudin-1-specific antibodies for the treatment of PSC. It is therefore of impact for physicians, scientists and drug developers in the field of biliary disease. |
Effect of Hypertension on Long-term Adverse Clinical Outcomes and Liver Fibrosis Progression in MASLD. Subgroup and sensitivity analyses supported these findings. Hypertension is a modifiable risk factor and increases risk of adverse clinical outcomes and progression of liver stiffness/fibrosis. |
| J Neurogastroenterol Motil |
Comparison of Fexuprazan and Esomeprazole for the Control of Nocturnal Gastroesophageal Reflux Symptoms: A Randomized, Crossover Study. Fexuprazan was more effective than esomeprazole in controlling nocturnal reflux symptom, particularly in patients with severe symptoms. Fexuprazan may offer a therapeutic advantage for patients with severe and persistent nocturnal reflux despite PPI therapy. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
Review Article: Impact of Alcohol Consumption on the Development and Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease. Alcohol amplifies MASLD progression through synergistic mechanisms. Standardised evaluation of alcohol use is critical for risk stratification and the development of personalised treatment strategies. |
| Clin Gastroenterol Hepatol |
DIAGNOSTIC AND MANAGEMENT REVIEW OF GASTRIC AND SUPRAGASTRIC BELCHING, AEROPHAGIA, AND RUMINATION SYNDROME. Further studies evaluating multidisciplinary behavioral therapy strategies with validated outcome measurement tools are needed to develop management guidelines and improve the lives of patients with these complex conditions. Evaluation for secondary causes is key to well-rounded, effective treatment. |
| Gastrointest Endosc |
| Hepatology |
| J Hepatol |
Sex-Related Variations in Liver Homeostasis and Disease: From Zonation Dynamics to Clinical Implications. For instance, men are more prone to develop MASLD and HCC, whereas women have a higher prevalence of autoimmune liver diseases and are at increased risk of accelerated fibrosis progression after menopause. New methods, such as digital twin models and innovative computer-assisted approaches, continue to advance our understanding of liver dimorphism, offering the prospect of personalised diagnosis and treatment strategies. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Gastrointest Endosc |
| Gut |
| J Hepatol |